The Panthers are 14-6 all-time against the Cardinals. Carolina is 8-4 at home and 6-2 on the road. The Panthers have also faced the Cardinals three times in the playoffs, going 2-1.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 11/19/95 | ARIZONA | W | 27-7 |
| 12/30/01 | ARIZONA | L | 7-30 |
| 10/6/02 | ARIZONA | L | 13-16 |
| 12/14/03 | at Arizona | W | 20-17 |
| 11/21/04 | ARIZONA | W | 35-10 |
| 10/9/05 | at Arizona | W | 24-20 |
| 10/14/07 | at Arizona | W | 25-10 |
| 10/26/08 | ARIZONA | W | 27-23 |
| 1/10/09 | ARIZONA | L | 13-33 (Divisional Playoffs) |
| 11/1/09 | at Arizona | W | 34-21 |
| 12/19/10 | ARIZONA | W | 19-12 |
| 9/11/11 | at Arizona | L | 21-28 |
| 10/6/13 | at Arizona | L | 6-22 |
| 1/3/15 | ARIZONA | W | 27-16 (Wild Card Playoffs) |
| 1/24/16 | ARIZONA | W | 49-15 (NFC Championship) |
| 10/30/16 | ARIZONA | W | 30-20 |
| 9/22/19 | at Arizona | W | 38-20 |
| 10/4/20 | ARIZONA | W | 31-21 |
| 11/14/21 | at Arizona | W | 34-10 |
| 10/2/22 | ARIZONA | L | 16-26 |