The Panthers are 4-8 all-time against the Bears. Carolina is 3-2 at home and 1-6 on the road. The Panthers are 1-0 against the Bears all-time in the playoffs.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 10/8/95 | at Chicago | L | 27-31 |
| 12/22/02 | CHICAGO | W | 24-14 |
| 11/20/05 | at Chicago | L | 3-13 |
| 1/15/06 | at Chicago | W | 29-21 (Divisional Playoffs) |
| 9/14/08 | CHICAGO | W | 20-17 |
| 10/10/10 | CHICAGO | L | 6-23 |
| 10/2/11 | at Chicago | L | 29-34 |
| 10/28/12 | at Chicago | L | 22-23 |
| 10/5/14 | CHICAGO | W | 31-24 |
| 10/22/17 | at Chicago | L | 3-17 |
| 10/18/20 | CHICAGO | L | 16-23 |
| 11/9/23 | at Chicago | L | 13-16 |