The Panthers are 4-4 all-time against the Jaguars. Carolina is 3-1 at home and 1-3 on the road at Jacksonville.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 9/29/96 | at Jacksonville | L | 14-24 |
| 9/19/99 | JACKSONVILLE | L | 20-22 |
| 9/7/03 | JACKSONVILLE | W | 24-23 |
| 12/9/07 | at Jacksonville | L | 6-37 |
| 9/25/11 | JACKSONVILLE | W | 16-10 |
| 9/13/15 | at Jacksonville | W | 20-9 |
| 10/6/19 | JACKSONVILLE | W | 34-27 |
| 12/31/23 | at Jacksonville | L | 26-0 |