The Panthers are 4-4 all-time against the Patriots. Carolina is 2-2 at home and 2-1 on the road at New England. The Panthers lost to the Patriots at a neutral site in Super Bowl XXXVIII.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 10/29/95 | at New England | W | 20-17 (OT) |
| 1/6/02 | NEW ENGLAND | L | 6-38 |
| 2/1/04 | vs. New England | L | 29-32 (Super Bowl XXXVIII) |
| 9/18/05 | NEW ENGLAND | W | 27-17 |
| 12/13/09 | at New England | L | 10-20 |
| 11/18/13 | NEW ENGLAND | W | 24-20 (MNF) |
| 10/1/17 | at New England | W | 33-30 |
| 11/7/21 | NEW ENGLAND | L | 6-24 |