The Panthers are 4-10 all-time against the Seahawks, and 1-2 in the playoffs. Carolina is 2-6 at home, and 1-0 at home in the playoffs. Carolina is 2-4 on the road at Seattle, and 0-2 during the playoffs on the road.
| Date | H/A | Result | Score (notes) |
|---|---|---|---|
| 10/8/00 | SEATTLE | W | 26-3 |
| 10/31/04 | at Seattle | L | 17-23 |
| 1/22/06 | at Seattle | L | 14-34 (NFC Championship) |
| 12/16/07 | SEATTLE | W | 13-10 |
| 12/5/10 | at Seattle | L | 14-31 |
| 10/7/12 | SEATTLE | L | 12-16 |
| 9/8/13 | SEATTLE | L | 7-12 |
| 10/26/14 | SEATTLE | L | 9-13 |
| 1/10/15 | at Seattle | L | 17-31 (NFC Divisional) |
| 10/25/15 | at Seattle | W | 27-23 |
| 1/17/16 | SEATTLE | W | 31-24 (NFC Divisional) |
| 12/4/16 | at Seattle | L | 7-40 (SNF) |
| 11/25/18 | SEATTLE | L | 27-30 |
| 12/15/19 | SEATTLE | L | 24-30 |
| 12/11/22 | at Seattle | W | 30-24 |
| 09/24/23 | at Seattle | L | 37-27 |
| 12/28/25 | SEATTLE | L | 27-10 |