Peyton and Eli Manning break down Jaycee Horn's second INT of the game with Panthers fan Luke Combs

Peyton Manning and Eli Manning break down Carolina Panthers cornerback Jaycee Horn's second interception against the San Francisco 49ers.

Watch the Panthers quarterback speak to the media after the 49ers game.

Listen to Canales address the media after the Panthers' Monday night game at San Francisco.

Former Carolina Panthers quarterback Jake Delhomme discusses his first NFL start against the Jacksonville Jaguars in 2003 on "Monday Night Football with Peyton Eli".

Former Carolina Panthers quarterback Jake Delhomme recalls the game he ripped his pants against the Atlanta Falcons in 2005.

Watch Panthers quarterback Bryce Young find receiver Tetairoa McMillan for a 29-yard touchdown.

Carolina Panthers quarterback Bryce Young hits running back Chuba Hubbard out of the backfield for a 14-yard catch and run after an electrifying juke move on a San Francisco 49ers defender.

Carolina Panthers running back Rico Dowdle makes multiple San Francisco 49ers defenders miss on an incredible spin move that results in a 17-yard run.

Watch kicker Ryan Fitzgerald connect on a 25-yard field goal to put the Panthers' on the board before the end of the first half.

Peyton Manning and Eli Manning show a viral video of Carolina Panthers 'theme song' with country singer and Panthers fan Luke Combs.

Watch Jaycee Horn intercept 49ers quarterback Brock Purdy's pass intended for receiver Ricky Pearsall.

Watch Mike Jackson intercept Brock Purdy on 3rd and 6, giving Carolina the ball back in the second quarter.

Watch this can't miss play as Panthers' defensive back Jaycee Horn intercepts 49ers quarterback Brock Purdy's pass meant for wide receiver Juan Jennings.

Watch the Panthers' coach give the Week 12 injury status of players and reflect on the team's improvement this season.

The Panthers' veteran spoke about the team staying level-headed as they get ready to play in a primetime game.

Watch Panthers' running back speak to the media on Friday after practice.

Brad Idzik spoke about the relationship growth he has seen in the receivers room, David Moore's leadership, and more.

Watch the Panthers' defensive coordinator speak about the matchup against San Francisco's offense,  the run game, and slowing down Christian McCaffrey.

Listen to the Panthers special teams coordinator speak to the media on Friday.

On this episode of the Panthers Huddle, the Panthers are playing in prime-time! Coach Canales is here as the team gets ready for a Monday Night match-up with the 49ers. Plus, step inside TD's film room as the Panthers legend breaks down a familiar face.

Watch the rookie wideout talk about his excitement for playing in primetime and his focus on being versatile on the field.

Watch the veteran tight end talk about the production from himself, Mitchell Evans and Ja'Tavion Sanders.

Watch the veteran defensive tackle discuss what makes Christian McCaffrey such a challenge to bring down and his philosophy in batting down balls at the line of scrimmage.

Canales spoke on facing familiar faces in the league - Robert Saleh and Christian McCaffrey - as the team prepares to play the San Francisco 49ers.

Cherelus spoke to the media about stepping into his role as a leader on defense.