The Saints are heavily favored by our weekly Pickin' It panelists to take care of Carolina on Monday Night Football, but a couple of analysts believe the Panthers will pull off a potential season-saving surprise at home.
Thirty-eight of the 40 prognosticators represented in the panel are siding with the Saints. The holdouts - hopeful holdouts from the Panthers' perspective - are Andrew Brandt for SI.com and Will Brinson for CBS Sports. Be sure to send them a Christmas card if their picks come through.
*Picks are tabulated using consensus among media outlet's staff
Sources: NFL.com, ESPN.com, SI.com, SB Nation, Sporting News, USA Today, Bleacher Report, CBS Sports
The Panthers trail the all-time series against the Saints, 27-29. Carolina has played New Orleans more than any other team in its history.
Carolina Panther Luke Kuechly (59) keeps his eyes on New Orleans Saint quarterback Drew Brees at Bank of American Stadium on Sunday, September 24, 2017 in Charlotte, NC.
Carolina Panthers' Rod Smart (32) runs past cheering teammates for a 100-yard kick return for a touchdown during the second quarter against the New Orleans Saints in Charlotte, N.C., Sunday Oct. 5, 2003. (AP Photo/Rick Havner)
Carolina Panthers play against the New Orleans Saints on Sunday, September 27, 2015 at Bank of America Stadium.
Carolina Panthers play against the New Orleans Saints on Sunday, December 22, 2013.
Carolina Panthers play against the New Orleans Saints on Sunday, December 22, 2013.
Carolina Panther Christian McCaffrey (22) makes a reception in the red zone against the New Orleans Saints at Bank of American Stadium on Sunday, September 24, 2017 in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, October 16, 2016 at the Mercedes Benz Super Dome in New Orleans, LA.
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, December 22, 2013.
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, October 16, 2016 at the Mercedes Benz Super Dome in New Orleans, LA.
Carolina Panthers play against the New Orleans Saints in Bank of America Stadium on Thursday, October 30, 2014 in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, December 22, 2013.
Carolina Panthers play against the New Orleans Saints on Sunday, December 22, 2013.
Carolina Panthers play against the New Orleans Saints on Sunday, December 6, 2015.
Carolina Panthers play against the New Orleans Saints on Sunday, September 27, 2015 at Bank of America Stadium.
Carolina Panthers play against the New Orleans Saints on Sunday, September 27, 2015 at Bank of America Stadium.
Carolina Panthers running back DeAngelo Williams in action during an NFL football game against the New Orleans Saints in Charlotte, N.C., Sunday, Oct. 19, 2008. (AP Photo/Chuck Burton)
Carolina Panther Curtis Samuel (10) evades New Orleans Saints Marcus Williams at Bank of American Stadium on Sunday, September 24, 2017 in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, October 16, 2016 at the Mercedes Benz Super Dome in New Orleans, LA.
New Orleans Saints defenders Roman Harper (41) and Jason David (42) try to defend Carolina Panthers wide receiver Steve Smith (89) in the second half of their NFL football game in the Superdome in New Orleans, Sunday, Dec. 28, 2008. Smith caught the long pass to keep the Panthers' game-winning drive alive as they defeated the Saints 33-31. (AP Photo/Chris Martinez)
Carolina Panthers play against the New Orleans Saints in Bank of America Stadium on Thursday, October 30, 2014 in Charlotte, NC.
New Orleans Saints' Drew Brees (9) looks to pass as Carolina Panthers' Julius Peppers (90) defends during the second quarter of an NFL football game in Charlotte, N.C., Sunday, Oct. 19, 2008. (AP Photo/Chuck Burton)
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
Carolina Panthers against the New Orleans Saints during the wild card round of the NFL playoffs at the Mercedes-Benz Superdome on Sunday, January 7, 2018 in New Orleans, LA. (Photo by Melissa Melvin-Rodriguez)
Carolina Panthers quarterback Jake Delhomme (17) scrambles as New Orleans Saints' Charles Grant (94) pursues during the second half of the Panthers' 30-7 win in an NFL football game in Charlotte, N.C., Sunday, Oct. 19, 2008. (AP Photo/Rick Havner)
The Carolina Panthers play against the Miami Dolphins during week ten of the regular season on Monday, November 13, 2017, at Bank of America Stadium in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, December 6, 2015.
New Orleans Saints quarterback Drew Brees (9) is sacked by Carolina Panthers outside linebacker Thomas Davis in the second half of an NFL football game in New Orleans, Sunday, Dec. 6, 2015. (AP Photo/Jonathan Bachman)
Carolina Panthers play against the New Orleans Saints in Bank of America Stadium on Thursday, October 30, 2014 in Charlotte, NC.
Carolina Panthers play against the New Orleans Saints on Sunday, December 6, 2015.
New Orleans Saints kicker Olindo Mare right, tries to grab the ball as Steve Weatherford (7) scrambles with Carolina Panthers Richard Marshall after the kick was blocked in the second half of their football game in the Superdome in New Orleans Sunday, Oct. 7, 2007. The Panthers won 16-13.(AP Photo/Alex Brandon)
Carolina Panthers receiver Steve Smith (89) gets by New Orleans Saints cornerback Fred Thomas on his way to a 15-yard, third-quarter touchdown during an NFL football game in Baton Rouge, La., on Sunday, Dec. 18, 2005. The Panthers won 27-10. (AP Photo/Paul Rutherford)
New Orleans Saints quarterback Drew Brees, bottom, lies on the field after being sacked by Carolina Panthers defender Richard Marshall (31) in the second half of their NFL football game in the Superdome in New Orleans, Sunday, Dec. 28, 2008.(AP Photo/Alex Brandon)
Carolina Panthers linebacker Mark Fields (58) celebrates sacking New Orleans Saints quarterback Aaron Brooks (2), center, on ground (partially obscured), at the Louisiana Superdome in New Orleans, Sunday, Dec. 29, 2002. The Panthers defeated the Saints, 10-6. On ground at right is Saints' Spencer Folau.(AP Photo/Doug Keese)
Carolina Panthers' Ken Lucas, left, intercepts a pass intended for New Orleans Saints' Marques Colston, right, during the third quarter of the Panthers' 30-7 win in an NFL football game in Charlotte, N.C., Sunday, Oct. 19, 2008. (AP Photo/Rick Havner)
Carolina Panthers quarterback Matt Moore (3) scrambles during an NFL football game against the New Orleans Saints in Charlotte, N.C., Sunday, Nov. 25, 2007. (AP Photo/Mike McCarn)
Carolina Panthers kicker John Kasay, center, is surrounded by his teammates after his field goal as time expired in an NFL football game in the Superdome in New Orleans on Sunday, Oct. 7, 2007. The Panthers won 16-13. (AP Photo/Alex Brandon)
The celebration begins as Carolina Panthers' Todd Sauerbrun (10) John Kasay (4) and Kris Mangum (86) enjoy their 23-20 victory over the New Orleans Saints, Sunday, Oct. 26, 2003, in the Louisiana Superdome in New Orleans. Kasay kicked the game-winning field goal in overtime. Leave the field for the Saints is Jay Bellamy (20). Holding for Kasay was punter Todd Souerbrun (10). (AP Photo/Andrew Cohoon)
New Orleans Saints defenders Johnathan Sullivan, left, and Brian Young (66) pursue Carolina Panthers quarterback Jake Delhomme (17) during the first half of an NFL football game at LSU's Tiger Stadium on Sunday, Dec. 18, 2005, in Baton Rouge, La. The Panthers won 27-10. (AP Photo/Bill Feig)
