Week 1 - Las Vegas Raiders (Sept. 13)
3 - This marks the third-straight season opener at home for Carolina, who hosted the Cowboys and Rams, respectively, the past two years. The last time the Panthers had at least three-straight home openers was when they had five from 2002-06.
The Panthers have never played the Raiders in September, much less in a season opener.
Week 2 - at Tampa Bay Buccaneers (Sept. 20)
6 - New Bucs quarterback Tom Brady has thrown just six touchdowns in five career regular-season games against the Panthers. Brady, who's 2-3 against Carolina in the regular season, also tossed five interceptions in those five matchups.
Week 3 - at Los Angeles Chargers (Sept. 27)
2 - This will be just the second time Carolina has ever played in the city of Los Angeles after beating the Rams in 2016. The Panthers will also be one of the first teams to play in the new SoFi Stadium.
Week 4 - Arizona Cardinals (Oct. 4)
11 - This year marks the 11th time the Cardinals have come to Charlotte, tied with the 49ers for the most by any West Coast team. The Panthers have hosted Arizona three times in the playoffs, more than any other opponent.
Week 5 - at Atlanta Falcons (Oct. 11)
58 - Christian McCaffrey has 58 receptions over the last three seasons against Atlanta. Those are the second-most by any player against a single opponent over three years during the Super Bowl era.
Week 6 - Chicago Bears (Oct. 18)
10 - In nine previous regular-season matchups, the Bears and Panthers have combined for 10 non-conventional touchdowns, including interception returns, defensive fumble returns, offensive fumble returns, punt returns and a blocked punt return.
Week 7 - at New Orleans Saints (Oct. 25)
95.4 - Teddy Bridgewater's career passing rating in eight games played in the Superdome, including seven as the Saints' backup quarterback the past two seasons.
Week 8 - Atlanta Falcons on Thursday Night Football (Oct. 29)
2000 - The last time Carolina didn't play Atlanta in November or December was in 2000. Both matchups this season will be played before November.
It also marks the first time the Panthers and Falcons will play in primetime at Bank of America Stadium.
Week 9 - at Kansas City (Nov. 8)
19 - Carolina has played the defending Super Bowl champions in 19 of its previous 25 regular seasons. The Panthers are 8-11 in those games, but recently, they won at New England in 2017 and at Philadelphia in 2018.
Week 10 - Tampa Bay Buccaneers (Nov. 15)
491 - The Panthers have scored 491 points against the Bucs over the last decade, the most against any opponent. Carolina has topped 30 points in seven of those 20 matchups.
Week 11 - Detroit Lions (Nov. 22)
4 - The Panthers have won their last four home games against the Lions after dropping their first meeting at Bank of America Stadium in 1999.
Week 12 - at Minnesota Vikings (Nov. 29)
4,046 - Running backs Christian McCaffrey (2,392) and Dalvin Cook (1,654) combined for a whopping 4,046 scrimmage yards in 2019. This meeting could be the first time both members of the 2017 draft class are on the same field after a knee injury kept Cook out of the Panthers win over the Vikings in 2017.
View photos of the Panthers 2020 opponents throughout the years.
Week 14 - Denver Broncos (Dec. 13)
4 - Only four combined starters remain from the last time these two met in the 2016 season opener: Panthers defensive tackle Kawann Short and safety Tre Boston and Broncos outside linebacker Von Miller and inside linebacker Todd Davis.
Week 15 - at Green Bay (Dec. 19 or 20)
37.7 - The average temperature for Carolina's seven road games at Lambeau Field, including a franchise-record NFC Championship game at 3 degrees in the 1996 season and a snowy 34-degree game last season. It may be cold again in Week 15.
Week 16 - at Washington Redskins (Dec. 27)
0 - The Panthers are 0-3 in games against former head coaches, so they'll look to break that streak when they visit Ron Rivera and his new team.
In 2003, Carolina lost to Dom Capers and the Texans. The Panthers also fell both times they played John Fox with Denver and Chicago (2014, 2017).
Week 17 - New Orleans Saints (Jan. 3)
18 - The Saints lead the all-time series, 26-25, with a total point differential of 18 (1,115-1,097). Six of the last 10 contests with New Orleans have been decided by five points or fewer.