Week 1 vs. Rams (Sept. 8)
4-1 - Carolina's record against the reigning NFC champions since 2015 in meetings with Philadelphia, Atlanta and Seattle. The Panthers have played the NFC champion every season since 2008.
Week 2 vs. Buccaneers (Sept. 12, Thursday Night Football)
110.4 - Cam Newton's passer rating in six games against Tampa Bay at home. Newton went 5-1 in those contests, averaging 231 passing yards and nearly two passing touchdowns per game.
Week 3 at Cardinals (Sept. 22)
422 - Passing yards by Newton in his first career game at Arizona in Week 1 of 2011. It marked the most passing yards by any NFL quarterback in his rookie debut.
Week 4 at Texans (Sept. 29)
4 - Number of total games Carolina has played against Houston, the fewest matchups between the Panthers and any other current NFL team. The all-time series is 2-2.
Week 5 vs. Jaguars (Oct. 6)
22 - Margin of total wins Carolina has over Jacksonville since both teams entered the NFL in 1995. Both franchises are celebrating 25 seasons in 2019 with Carolina holding a 199-201 all-time record and Jacksonville standing at 177-221.
Week 6 at Buccaneers in London (Oct. 13)
6,419 - Kilometers from Charlotte to Tottenham Hotspur Stadium in London, home of Carolina's first international game and the farthest road game in franchise history.
Week 8 at 49ers (Oct. 27)
70.0 - Carolina's win percentage (7-3) in road games against San Francisco (both teams were in the NFC West back in the day). Since 1995, only Dallas (5-1) and Green Bay (4-1) have a better winning percentage at the 49ers.
Week 9 vs. Titans (Nov. 3)
0 - Number of home wins that Carolina has against the Tennessee Titans. The Titans are the only team that Carolina has never beaten in Charlotte, going 0-2 at home. That can change in Week 9.
Week 10 at Packers (Nov. 10)
3 - Degrees Fahrenheit in Carolina's coldest game in franchise history, the NFC Championship contest at Lambeau Field on Jan. 12, 1997. This year's game in Week 10 is Carolina's last road game outdoors with three games at Atlanta, New Orleans and Indianapolis following in November and December.
Week 11 vs. Falcons (Nov. 17)
26 - Total receptions by Christian McCaffrey in two games against the Falcons in 2018. He tied Steve Smith's single-game franchise record with 14 catches at Atlanta in Week 2 and then posted 12 catches at home against Atlanta in Week 16. It marked the most receptions by a running back against an opponent in one regular season in NFL history.
Week 12 at Saints (Nov. 24)
12 - Total point differential in the all-time series against New Orleans, which Carolina leads 1,082 -1,070. The Panthers have a 25-24 edge in the all-time series against Carolina's most common opponent.
Week 13 vs. Redskins (Dec. 1)
6 - Wins in eight games by Carolina over the Redskins since divisional realignment in 2002. The Redskins started the all-time series with six consecutive victories between 1995 and 2001, so they're clinging to an 8-6 edge overall.
Week 14 at Falcons (Dec. 8)
7 - Players that attended high schools in the state of Georgia on the current Panthers roster.
Week 15 vs. Seahawks (Dec. 15)
10 - This year marks the 10th meeting between Seattle and Carolina since 2010, including the playoffs. It marks the most games against any team outside of the division in that stretch.
Week 16 at Colts (Dec. 22)
3:50 - The length of time of Carolina's third-longest game in franchise history – a home overtime win on Monday Night Football in the last meeting with the Colts in 2015. Two of Carolina's five all-time wins over Indianapolis have come in overtime.
Week 17 vs. Saints (12/29)
10th - Time that Carolina has closed the regular season with a game against the New Orleans Saints in franchise history. The Saints are Carolina's most common year-ending opponent.
Additionally, Carolina has only finished the regular season at home once in the Ron Rivera/Cam Newton era, and that was in...2015.
Scroll through pictures of Carolina playing its 2019 opponents.