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Know Your Foe: Arizona Cardinals 

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CHARLOTTE— The Panthers are kicking off their NFC slate this weekend with a showdown in the desert against the Arizona Cardinals. This series has become one of the more exciting ones in recent years. In the 2014 season, Carolina beat Arizona in the NFC Wild Card Playoffs, and again the next season in the NFC Championship. Those led off a six-game win streak against the Cards and the Panthers got back to the winning side last season with an overtime walk off win courtesy of Chuba Hubbard.

Overall, the Panthers lead the series 15-6 all-time. Carolina is 9-4 at home and 6-2 on the road. The Panthers have also faced the Cardinals three times in the playoffs, going 2-1.

The Cardinals faced a NFC South opponent Week 1 as well, defeating the New Orleans Saints 20-13. Before the Panthers start their week of preparation and travel, get to know the Arizona Cardinals.

Kyler Murray's impact

Since getting drafted No. 1 overall in 2019, Murray has been an enigma, winning Offensive Rookie of the Year in 2019 and making two Pro Bowls (2020, 2021) but only going to one playoff game, falling in 2021 to the Rams. But he's a dynamic quarterback, always happy to move around and look for a play from anywhere on the field, as well as scrambling for yardage himself if need be.

Against the Saints, he went 21-29 for 163 yards and two touchdowns, as well as rushing seven times for 38 yards. According to Next Gen Stats, both touchdown passes came against the blitz.

He completed 8 of 10 passes for 71 yards against the blitz on the day, recording a passer rating of 135.8 after finishing with a 79.0 passer rating (4th-lowest in NFL) against the blitz last season. Murray targeted pass catchers behind the line of scrimmage on 31.0% of his attempts (6th-highest rate in a game in his career), completing all nine for 20 yards and a touchdown.

He did take five sacks for 33-yards against the Saints.

Last season, in the late December matchup against the Panthers, Murray went 20-32 for 202 yards with one touchdown and one interception, adding eight rushes for 63 yards and another score on the ground, while taking three sacks.

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The Cardinals two headed receiving monster

Kyler Murray has two drastically different receiving options in the pass game, in second year receiver Marvin Harrison Jr. and fourth-year tight end Trey McBride, the latter of whom is coming off a 1,000-yard season (1,146 total). The duo finished as first and second respectively for the Cardinals on Sunday: Harrison had five receptions for 71 yards and a touchdown. McBride brought in six receptions for 61 yards. The Panthers were able to hold McBride relatively in check last season, keeping him to three receptions for 20 yards, and Harrison Jr. to four receptions on eight targets for 39 yards.

Arizona Cardinals wide receiver Marvin Harrison Jr., right, makes a touchdown catch against New Orleans Saints cornerback Kool-Aid McKinstry during the first half of an NFL football game Sunday, Sept. 7, 2025, in New Orleans. (AP Photo/Gerald Herbert )

In his rookie season, Marvin Harrison Jr. faced press coverage in 31.2% of his routes, which ranked 15th among wide receivers (min. 300 routes).

Harrison and Murray talked a lot this offseason about strengthening their connection, and working on finding more chemistry than they had in 2024.

"We knew that's something that for the team to reach its goal, something that we got to do better than we did last year," Harrison said, according to ESPN.

Arizona Cardinals cornerback Will Johnson (0) celebrates after a play during an NFL football game against the New Orleans Saints, Sunday, Sept. 7, 2025 in New Orleans. (Kevin Sabitus via AP)

The veteran and the rookie

Budda Baker has always been a menace to deal with, and that seems to still be the case through Week 1 of this season. He finished with a game-high 10 tackles, one for loss, and a pass defended against the Saints. Now the linebacker seemingly has a counterpart on the backend with rookie corner Will Johnson. The Michigan product had one tackle, but three passes defended. He allowed 3 completions for just 26 yards on 6 targets (including 3 passes defensed) as the nearest defender in coverage in his NFL debut against the Saints. According to Next Gen Stats, Johnson forced a tight window on three of his six targets (50%); Cardinals cornerbacks forced a tight window rate of 21.6% (12th-lowest in NFL) last season.

Carolina is 14-6 all-time against the Cardinals, including a 2-1 record in the playoffs.

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