CHARLOTTE – Cornerback Bene Benwikere fractured his left leg in the second half of Sunday's 38-0 victory over the Falcons.
Benwikere, typically Carolina's nickel corner, had started four consecutive games on the outside with Charles Tillman recovering from a knee injury.
Head coach Ron Rivera said Benwikere will "more than likely" be placed on season-ending injured reserve.
"We'll get an opportunity to visit with (general manager) Dave (Gettleman) and his staff and the coaches, but we are going to have to do something," Rivera said. "These next couple days are going to be very critical for where Peanut is, and it might influence our decision."
Benwikere has played in every game thus far and ranks second on the team with nine passes defensed.
"It's tough. Bene is becoming such a better player. He's such a key asset to us on this defense," safety Kurt Coleman said. "I'm praying for him, but I know what we have in this locker room. We've got guys that can step up and make plays down the stretch."
With Benwikere out, Tillman, Josh Norman, Cortland Finnegan and Teddy Williams are the remaining corners on the active roster. Safety Colin Jones, who has spent considerable time at nickel, suffered a groin injury during Sunday's game and did not return.
View game action photos from Carolina's 38-0 win over Atlanta.