- Carolina is now 4-9 against Seattle all-time, with the Seahawks winning the last two games.
- The Panthers snapped a 10-game home winning streak which was tied for the longest active streak in the NFL. It tied for the second-longest home winning streak in franchise history.
- Carolina tallied 476 net yards of offense, the most this season.
- The Panthers scored touchdowns on 3-of-7 red zone trips (43 percent). The Panthers entered the game with a touchdown percentage of 73.5 percent.
- The Panthers did not force a turnover for the third-straight game.
- The Seahawks rushed for only 75 yards, their fewest since Week 2. Seattle had played eight straight games with at least 100 yards rushing.
- Christian McCaffrey became the first player in franchise history with over 100 yards rushing and 100 yards receiving. His 237 scrimmage yards (125 rushing, 112 receiving) set a franchise record for scrimmage yards in a game (Stewart, 222, 2009).
- Cam Newton set a franchise record with 16 consecutive completions dating back to the Detroit game, breaking Steve Beuerlein's previous record of 15 (1999). He went a perfect 14-of-14 in the first half, the most completions without an incompletion in the first half in franchise history.
- Newton completed his 10th consecutive game with at least two touchdown passes, extending his franchise record. He also posted his sixth-straight game with a passer rating over 100, extending his franchise record and tying for the fourth-longest streak in the NFL since 2008.
- DJ Moore set a new career high with eight receptions for 91 receiving yards. Over the last two weeks, Moore has tallied 248 receiving yards, the most by a rookie wide receiver over two games in franchise history.
- Graham Gano hit 41 straight field goals at home before his miss in the fourth quarter from 52 yards.
- Seahawks receivers Tyler Lockett (107) and David Moore (103) each eclipsed 100 yards receiving, marking the first time the Panthers surrendered two 100-yard receiving games since 11/26/17 against the Jets.