- With kicker Zane Gonzalez injured pregame, the Panthers had five fourth-down attempts, converting just one for a first down. It tied for the second-most fourth down attempts in franchise history (the record remains seven in 2001). As a whole, the Panthers converted 8-of-22 conversion attempts on third and fourth down.
- The Panthers rushed for 151 yards on 29 carries for a 5.2 average. It was their third-most rushing yards in a game this season and second-highest rushing average.
- Carolina's defense totaled four sacks and six quarterback hits, tied for its second-most sacks this season and most since Week 10 at Arizona.
- The Panthers held the Bills to 193 passing yards and 312 total yards, the third-lowest passing output by Buffalo this season.
- Carolina had five penalties for 55 yards, including two personal fouls that extended Bills' scoring drives.
- Quarterback Cam Newton scored a rushing touchdown for the fifth-straight game, tying Arizona's Kyler Murray (5, 2020) for the longest such streak by a quarterback in the NFL's Super Bowl era.
- Newton recorded his 44th career game with at least a rushing and passing touchdown, the most in NFL history and 13 more than second-place (Steve Young, 31).
- Running back Ameer Abdullah had 48 receiving yards and his first touchdown as a Panther on a 23-yard catch and run. He is the 10th different Panther with a touchdown this season.
- Defensive end Yetur Gross-Matos had a career-best game, totaling five total tackles, 2.5 sacks, three QB hits, a tackle for loss and a forced fumble.
- Safety Jeremy Chinn had a team-high seven tackles and his first interception of the season. He is now just two tackles away from a 100-tackle season.
- Brandon Zylstra became the first NFL wide receiver with three kickoffs in one game in the modern era. He averaged 48.7 yards per kick.
View photos of game action between Carolina and Buffalo in Week 15 of the 2021 season.