- The Panthers offense utilized two quarterbacks, who combined for 22-of-45 passing for 251 yards. As a whole, the offense managed 273 net yards and was held out of the end zone for the first time since Week 9 against New England.
- Carolina's defense allowed 391 net yards to Tampa Bay, the third-most allowed by the Panthers this season. The Buccaneers had chunk plays of 55 yards and 62 yards, the longest run and pass plays allowed by Carolina this year, respectively.
- The Panthers went 7-of-20 on third and fourth downs (35.0 percent), while the Bucs were 7-of-14 (50.0 percent).
- The Panthers allowed seven sacks, their most since 2019 (Week 13 vs. Washington).
- Wide receiver DJ Moore had five catches for 55 yards putting him over 1,000 receiving yards for the season. Moore became just the third player in Panthers' history (Steve Smith Sr., Greg Olsen) to record three consecutive seasons with over 1,000 yards.
- Safety Jeremy Chinn had five tackles to top 100 on the season. He joins Jon Beason and Luke Kuechly as the only Panthers with 100 tackles in each of their first two seasons.
- Quarterback Sam Darnold had 190 passing yards on 15-of-32 passing while Cam Newton had 61 passing yards on 7-of-13 passing with 42 rushing yards. Darnold's 63-yard pass play to Shi Smith was the longest by Darnold as a Panther.
- Yetur Gross-Matos had two tackles for loss and a pass deflection. In the past two weeks, Gross-Matos has had 2.5 sacks and three tackles for loss.
View photos of the Panthers taking on Tampa Bay in the 2021 home finale in Week 16.